monoamine oxidase b การใช้

• "' Safinamide "'( monoamine oxidase B inhibiting and other methods of action.
• It has been found to act as a inhibitor of monoamine oxidase B.
• In contrast, Monoamine oxidase B ( MAOB ) mainly metabolizes dopamine ( DA ) ( and other less clinically relevant chemicals ).
• Methamphetamine is also an agonist of the alpha-2 adrenergic receptors and sigma receptors with a greater ? 2, and inhibits monoamine oxidase A ( MAO-A ) and monoamine oxidase B ( MAO-B ).
• "' Mofegiline "'( "'MDL-72, 974 "') is a inhibitor of monoamine oxidase B ( MAO-B ) and semicarbazide-sensitive amine oxidase ( SSAO ) which was under investigation for the treatment of Parkinson's disease and Alzheimer's disease, but was never marketed.
• The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders : Monoamine oxidase A inhibitors have been typically used in the treatment of depression, and monoamine oxidase B inhibitors are typically used in the treatment of Parkinson's disease.
• Unlike many synthetic pharmaceutical MAOIs such as phenelzine, harmine is selective meaning it does not have nearly as high a risk for the " cheese syndrome " caused by consuming tyramine-containing foods, which is a risk associated with monoamine oxidase A inhibitors, but not monoamine oxidase B inhibitors.
• In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after orally ingested phenethylamine is primarily metabolized in the small intestine by monoamine oxidase B ( MAO-B ) and then aldehyde dehydrogenase ( ALDH ), which convert it to phenylacetic acid.
• The researchers said they have so far been unable to identify the ingredient in tobacco smoke that inhibits the dopamine-destroying enzyme, which is known as monoamine oxidase B or MAO B . Discovery of the new MAO B mechanism, they said, may help in developing more effective ways treat or block cigarette addiction.
• A team led by Joanna Fowler of the Brookhaven National Laboratory in Upton, N . Y ., found that compared to the other groups, smokers on average have about 40 percent less of a brain enzyme called monoamine oxidase B, or MAO B . That enzyme destroys dopamine, a pleasure-producing brain chemical _ so the net effect is that smoking raises dopamine levels.